What is the best painkiller for a toothache? Tooth pain is one of the excruciating conditions a person can experience. Generally speaking, it can affect even the other body parts once the pain is tremendous. For this reason, people often look for painkillers to relieve dental pain. The dentist is the best person to ask for help regarding the best painkiller for toothache. Some may even include home remedies, but we need to see a dentist for permanent options to counter pain. So, let's move forward and see what we can apply for pain relief.